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Twenty20to 25 mg/kg body weightSplitting the total therapeutic dose into 2 doses taken 6 to 8 hours apart may reduce the occurrence or severity of adverse effectsExperience with Lariam in pediatric patients weighing less than 20 kg is limitedThe drug should not be taken on an empty stomach and should be administered with ample waterThe tablets may be crushed and suspended in a small amount of watermilk or other beverage for administration to small children and other persons unable to swallow them whole.

Parenteral studies in animals show that mefloquinea myocardial depressantpossesses 20of the anti-fibrillatory action of quinidine and produces 50of the increase in the PR interval reported with quinineThe effect of mefloquine on the compromised cardiovascular system has not been evaluatedHowevertransitory and clinically silent ECG alterations have been reported during the use of mefloquineAlterations included sinus bradycardiasinus arrhythmiafirst degree AV-blockprolongation of the QTc interval and abnormal T wavessee also cardiovascular effects under PRECAUTIONSDRUG INTERACTIONS and ADVERSE REACTIONSThe benefits of Lariammefloquinetherapy should be weighed against the possibility of adverse effects in patients with cardiac disease.

Parenteral studies in animals show that mefloquinea myocardial depressantpossesses 20of the anti-fibrillatory action of quinidine and produces 50of the increase in the PR interval reported with quinineThe effect of mefloquine on the compromised cardiovascular system has not been evaluatedHowevertransitory and clinically silent ECG alterations have been reported during the use of mefloquineAlterations included sinus bradycardiasinus arrhythmiafirst degree AV-blockprolongation of the QTc interval and abnormal T wavessee also cardiovascular effects under PRECAUTIONSDRUG INTERACTIONS and ADVERSE REACTIONSThe benefits of Lariammefloquinetherapy should be weighed against the possibility of adverse effects in patients with cardiac disease.

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