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African-americans may need to be titrated to higher dosages to achieve the target prograf concentrations 2.

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It is not known whether Prograf will harm an unborn babyTell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is recommended that patients initiate oral therapy with Prograf capsules if possibleInitial dosage and observed tacrolimus whole blood trough concentrations for adults are shown in Table 1 and for pediatrics in Table 3see Dosage In Adult KidneyLiverOr Heart Transplant Patientsfor blood concentration monitoring details in kidney transplant patientssee Dosage In Adult KidneyLiverOr Heart Transplant Patients

Prograf injection should be reserved for patients unable to take Prograf capsules orallysee DOSAGE AND ADMINISTRATION and WARNINGS AND PRECAUTIONS

The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongationBefore using tacrolimustell your doctor or pharmacist of all the drugs you take and if you have any of the following conditionscertain heart problemsheart failureslow heartbeatQT prolongation in the EKGfamily history of certain heart problemsQT prolongation in the EKGsudden cardiac death

Nervous system problemsconfusionheadachevision problemstremorsnumbness and tingly feelingseizureconvulsionsor.

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