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The most common adverse reactions in treated patientsincidence2which were not identified in the trichomoniasisgiardiasis and amebiasis studiesare gastrointestinaldecreased appetiteand flatulencerenalurinary tract infectionpainful urinationand urine abnormalityand other reactions including pelvic painvulvo-vaginal discomfortvaginal odormenorrhagiaand upper respiratory tract infectionSee Clinical Studies

For those unable to swallow tabletstinidazole tablets may be crushed in artificial cherry syrupto be taken with foodsee DOSAGE AND ADMINISTRATION

Convulsive seizures and peripheral neuropathythe latter characterized mainly by numbness or paresthesia of an extremityhave been reported in patients treated with tinidazoleThe appearance of abnormal neurologic signs demands the prompt discontinuation of tinidazole therapy.

Tinidazole is a prodrug and antiprotozoal agentThe nitro group of tinidazole is reduced in Trichomonas by a ferredoxin-mediated electron transport systemThe free nitro radical generated as a result of this reduction is believed to be responsible for the antiprotozoal activityIt is suggested that the toxic free radicals covalently bind to DNAcausing DNA damage and leading to cell deathThe mechanism by which tinidazole exhibits activity against Giardia and Entamoeba species is not knownthough it is probably similar.

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