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In the UKlive vaccines include rubellamumpsmeaslesBCGyellow fever and shingles vaccineZostavax
The level of phenytoin should be carefully monitored in patients taking XELODA and phenytoin dose may need to be reducedsee DOSAGE AND ADMINISTRATIONPostmarketing reports indicate that some patients receiving XELODA and phenytoin had toxicity associated with elevated phenytoin levelsFormal drug-drug interaction studies with phenytoin have not been conductedbut the mechanism of interaction is presumed to be inhibition of the CYP2C9 isoenzyme by capecitabine and/or its metabolites.
XELODA in combination with docetaxel resulted in statistically significant improvement in time to disease progressionoverall survival and objective response rate compared to monotherapy with docetaxel as shown in Table 17Figure 4and Figure 5.
Because clinical trials are conducted under widely varying conditionsadverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.
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