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In overdosetablets of Isoptin SR have occasionally been reported to form concretions within the stomach or intestinesThese concretions have not been visible on plain radiographs of the abdomenand no medical means of gastrointestinal emptying is of proven efficacy in removing themEndoscopy might reasonably be considered in cases of massive overdose when symptoms are unusually prolonged.
TheophyllineVerapamil therapy may inhibit the clearance and increase the plasma levels of theophylline.
Elevated Liver EnzymesElevations of transaminases with and without concomitant elevations in alkaline phosphatase and bilirubin have been reportedSuch elevations have sometimes been transient and may disappear even in the face of continued verapamil treatmentSeveral cases of hepatocellular injury related to verapamil have been proven by rechallengehalf of these had clinical symptomsmalaisefeverand/or right upper quadrant painin addition to elevations of SGOTSGPT and alkaline phosphatasePeriodic monitoring of liver function in patients receiving verapamil is therefore prudent.
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