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Although beta-adrenergic receptor blockade is useful in the treatment of angina and hypertensionthere are also situations in which sympathetic stimulation is vitalFor examplein patients with severely damaged heartsadequate ventricular function may depend on sympathetic driveBeta-adrenergic blockade may worsen A-V block by preventing the necessary facilitating effects of sympathetic activity on conductionBeta 2adrenergic blockade results in passive bronchial constriction by interfering with endogenous adrenergic bronchodilator activity in patients subject to bronchospasmand it may also interfere with exogenous bronchodilators in such patients.

FDA pregnancy category CIt is not known whether labetalol will harm an unborn babyLabetalol may cause heart or lung problems in a newborn if the mother takes the medication during pregnancyTell your doctor if you are pregnant or plan to become pregnant while using this medication.

Labetalol may impair your thinking or reactionsBe careful if you drive or do anything that requires you to be alert.

Asthma2 ndor 3 rddegree AV blockOvert cardiac failureCardiogenic shockSevere bradycardiaother conditions associated with prolonged or severe hypotension.

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