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In people with intolerance to modified-release dipyridamole, clopidogrel followed by aspirin had an icer of 4000 per qaly gained compared with aspirin alone.
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Concomitant therapy with lopid and an hmgcoa reductase inhibitor is associated with an increased risk of skeletal muscle toxicity manifested as rhabdomyolysis, markedly elevated creatine kinase cpk levels, and myoglobinuria, leading in a high proportion of cases to acute renal failure and death.
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Today, the combination of clopidogrel and aspirin is given to virtually all people who receive a stent.
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